演員表
- 導演：
- 編劇：
- 史丹李 Stan Lee ............(comic book)
- 史蒂夫迪特科 Steve Ditko ............(comic book)
- 演員：
- 陶比麥奎爾 Tobey Maguire ............Spider-Man/Peter Parker
- 威廉達佛 Willem Dafoe ............Green Goblin/Norman Osborn
- 克絲汀鄧斯特 Kirsten Dunst ............Mary Jane Watson
- 詹姆斯法蘭科 James Franco ............Harry Osborn
- JK 西蒙斯 J.K. Simmons ............J. Jonah Jameson
- Michael Papajohn ............The Burglar
- Randy Poffo ............Bone Saw McGraw
- 喬曼格尼洛 Joe Manganiello ............Eugene 'Flash' Thompson
- 蘿絲瑪麗哈里斯 Rosemary Harris ............Aunt May
- Ted Raimi ............Hoffman
- 克里夫勞勃遜 Cliff Robertson ............Uncle Ben Parker
- 比爾努恩 Bill Nunn ............Joe 'Robbie' Robertson
- 布魯斯坎貝爾 Bruce Campbell (Ⅰ) ............Ring Announcer
- 史丹李 Stan Lee ............Man in Fair (uncredited)
- Peter Appel ............Taxi Cab Driver
- Joni Avery ............Cop #2
- Rick Avery ............Cop #3
- 伊莉莎白班克斯 Elizabeth Banks (Ⅱ) ............Betty Brant
- Jayce Bartok ............Street Performer
- Brian Bennett (Ⅴ) ............Door Man #1
- Alex Black ............Boy in Tram
- Jophery C. Brown ............Chef #1
- Samantha Brown (Ⅱ) ............47th Street Burglar
- Jacob Chambers ............Cop #8
- 吉莉安·克萊兒 Jillian Clare ............Girl #2 in Tram
- Chris Coppola ............Kyle
- Chandra De Alessandro ............Cop #5
- Mark De Alessandro ............Cop #4
- Richard C. Everbeck ............Eddie Brock
- Jeanie Fox ............New Yorker #4
- Al Goto ............Cop #1
- Macy Gray ............Herself
- Shane Habberstad ............Little Billy
- Randy Hall ............Cop #7
- Kevin Jackson (Ⅰ) ............Bell Man #1
- Kolby Kirk ............Festival Guest #1
- Erik Kleven ............Chef #2
- Brendan Morante ............Man in Street
- Justin Neill ............Flash Thompson's Crony #2
- Debra Orenstein ............Doctor #1
- Scott L. Schwartz ............Wrestler
- Robair Sims ............Bell Man #2
- Deborah Wakeham (Ⅰ) ............Billy's Mom
- 奧塔薇亞史班森 Octavia Spencer ............Check-In Girl
