演員表
- 導演：
- 編劇：
- Marc Hyman ............(written by)
- 演員：
- 克里斯洛克 Chris Rock ............Osmosis Jones
- 勞倫斯費許朋 Laurence Fishburne ............Thrax
- 大衛海德皮爾斯 David Hyde Pierce ............Drix
- 白蘭蒂 Brandy Norwood ............Leah (voice)
- 威廉沙特納 William Shatner ............Mayor Phlegmming
- 摩利蘇恩 Molly Shannon ............Mrs. Boyd
- 克里斯艾略特 Chris Elliott (Ⅰ) ............Bob
- 比爾墨瑞 Bill Murray ............Frank Pepperidge
- 喬西佛 Joel Silver ............The Chief
- Joe C. ............White Blood Cell
- Elizabeth Farrelly Jordan ............Nurse
- A.B. Farrelly ............Bus Girl
- Kathy Farrelly ............Nurse
- Kevin J. Flynn ............Docky's Clamshack Waiter
- Nicki Tyler Flynn ............Nurse
- Elena Franklin ............Shane
- Zen Gesner ............Doctor
- 朗霍華 Ron Howard ............Tom Colonic (voice)
- Kelsey Jordan ............Bus Girl
- Thomas Jordan ............The Zoo Visitors & Staff
- Kid Rock ............White Blood Cell
