演員表
- 導演:
- 編劇:
- 演員:
- 陶比麥奎爾 Tobey Maguire ............Peter Parker/Spider-Man
- 克絲汀鄧斯特 Kirsten Dunst ............Mary Jane Watson
- 詹姆斯法蘭科 James Franco ............Harry Osborn
- 湯馬斯海登喬許 Thomas Haden Church ............Flint Marko/Sandman
- 陶佛葛瑞斯 Topher Grace ............Eddie Brock
- 布萊絲達拉斯霍華 Bryce Dallas Howard ............Gwen Stacy
- 泰瑞莎羅素 Theresa Russell ............Mrs. Marko
- 比爾努恩 Bill Nunn ............Joseph 'Robbie' Robertson
- Tanya Sinovec ............Jazz Club Waitress
- Dawn Marie Anderson ............Nurse
- Robert N. Anderson ............Lab Technician
- Terrell Anthony ............Lab Technician
- 伊莉莎白班克斯 Elizabeth Banks (Ⅱ) ............Betty Brant
- Jodi Benker ............Woman in Nightclub
- JK 西蒙斯 J.K. Simmons ............J. Jonah Jameson