演員表
- 導演:
- 編劇:
- 演員:
- 陶比麥奎爾 Tobey Maguire ............Peter Parker/Spider-Man
- 克絲汀鄧斯特 Kirsten Dunst ............Mary Jane Watson
- 艾佛烈蒙利納 Alfred Molina ............Dr. Otto Octavius/Dr. Octopus
- 詹姆斯法蘭科 James Franco ............Harry Osborn
- 伊莉莎白班克斯 Elizabeth Banks (Ⅱ) ............Betty Brant
- 布魯斯坎貝爾 Bruce Campbell (Ⅰ) ............Snooty Usher
- 蘿絲瑪麗哈里斯 Rosemary Harris ............Aunt May
- JK 西蒙斯 J.K. Simmons ............J. Jonah Jameson
- Vanessa Ferlito ............Louise
- Ted Raimi ............Hoffman
- 比爾努恩 Bill Nunn ............Joseph 'Robbie' Robertson
- 狄倫貝克 Dylan Baker ............Dr. Curt Connors
- Joanne Baron ............Jane Brown
- Gelbert Coloma ............Korean Investor
- Christina Della Rose ............Nurse
- Elyse Dinh ............Street Musician
- 丹尼爾吉爾斯 Daniel Gillies ............John Jameson
- Michelle Grey ............Lab Assistant
- Claudia Katz ............Robbie's Assistant
- 金大賢 Daniel Dae Kim ............Raymond
- Aasif Mandvi ............Aziz
- 喬爾麥克哈爾 Joel McHale ............Mr. Jacks
- 多納墨非 Donna Murphy ............Rosalie Octavius